Are Mood Disorders Actually Metabolic Diseases Rooted in Insulin Resistance?
Story at-a-glance Bipolar disorder and depression affect tens of millions globally, long treated as strictly brain-based illnesses, yet both consistently show high rates of insulin resistance and metabolic disturbances A 2025 Nature Neuroscience study found that pancreatic insulin release and hippocampal activity are linked through a circadian feedback loop. This suggests bipolar mood shifts arise…
